Brain Damage Studies
Patients with increased functional connectivity between the brainโs different regions who had also experienced childhood trauma had a subtype of depression that was non-responsive to treatment by SSRIs drugs. Specifically, the brainโs functional connectivity in regions involving the angular gyrus โ played a large role in determining whether SSRIs were effective in treating depression.
On the other hand, the other two subtypes โ where the participantsโ brains did not show increased connectivity among its different regions or where participants had not experienced childhood trauma โ tended to respond positively to treatments using SSRIs drugs. (Source: psychcentral.com)